THE WORLD'S NATURAL MEDICINE is found in the Peruvian Amazon

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Gold of the Jungle: Medicinal Plants in the Amazon Rainforest

The Amazon Rainforest is full of yet-to-be-discovered medicines and chemicals coveted by scientists worldwide. But indigenous people in the Amazon, of course, have known the power of rainforest plants for thousands of years! During a recent visit to the Posada Amazonas and Refugio Amazonas lodges, I visited the lush garden of the Ese Eja People to discover jungle healing for myself. To give you a taste of these traditional healing practices, I’ve included seven of the most important Medicinal plants in the amazon rainforest used in Tambopata, and around the Amazon basin.

1. Ayahuasca

Ayahuasca

Ayahuasca or Banisteriopsis caapi – Photo by Jeff Cremer

In Quechua, Ayahuasca (Banisteriopsis caapi) means “vine of the soul” or “vine of the dead.” In recent years, the plant has received worldwide attention — both good and bad — as a psychedelic drug that travelers seek out for a bohemian “trip.” But the reality of Ayahuasca is much closer to that original meaning. For centuries, probably longer, Amazonian indigenous people have macerated and boiled the plant to use in sacred, ritual practice. Shamans use Ayahuasca to connect their patients with the spiritual realm or their ancestors, and for other medicinal purposes.

2. Chacruna

Chacruna

Chacruna or Psychotria viridis – Photo by Alden Wicker

 

While many people think of Ayahuasca as a single, psychotropic plant, Shamans in the Tambopata area actually mix the vine with Chacruna, a small shrub, for spiritual ceremonies. Chacruna (Psychotria viridis) contains the hallucinogenic chemical DMT, which mixes with the MAOI anti-depressant compound in Ayahuasca to make a potent brew.

Today, this combination of the Ayahuasca and Chacruna plants (or similar plants with DMT) has reached far beyond the Amazon itself. Several churches and spiritual movements, most notably the Brazilian Santo Daime Church, have spread Ayahuasca’s psychedelic practice worldwide. The use of the plants has incited controversy and challenging legal and cultural questions: What tensions may exist between indigenous people using the Ayahuasca brew traditionally, and North Americans and Europeans using it to have a personal psychedelic journey? Should the plants’ use be legal internationally?

3. Uña de Gato or Cat’s claw

Uña de gato

Uña de Gato or Cat’s claws. Photo by AndeanNatural.com

The tall vines of Uña de Gato curve upwards around tree trunks, with tiny, twisted green thorns under the leaves — giving rise to the plant’s name, “Cat’s Claw” in English. Amazonian peoples use Uña de Gato’s roots as a “cure-all” medicine for everything from rheumatism pain to toothaches, deep injuries to ulcers. Since European scientists encountered the Amazon plant in 1830, it’s become common around the globe. Several varieties serve different healing purposes in North America and Europe, and a different type is common in Chinese medicine.

Today, Uña de Gato is a popular herbal supplement, and scientists have begun to study the root. So far, they’ve discovered that the plant may help regulate the immune system, have anti-inflammatory properties, and possibly fight viruses or bacteria as well! One of Uña de Gato’s traditional uses is slightly less, well, medical, but perhaps just as useful: in the Peruvian Amazon, some consider it an aphrodisiac.

4. Achiote or Annatto

Achiote

You might not recognize Achiote’s spiky, bright red fruit at first glance, but if you’ve traveled in Latin America, chances are you’ve tasted it! Cooks add the crushed seeds of the Achiote tree (Bixa orellana) to dishes to give them yellow or orange color, along with a slightly peppery, nutty flavor. But Achiote, also called Annatto, is much more than a tasty ingredient. Amazonian indigenous groups have used it for ritual body painting, sunscreen, insect repellent, and more. Some people use the leaves as well, boiling them to treat fevers or speed up the healing of wounds. Recently, scientists have studied Achiote more formally, and so far they’ve found that it contains carotenoids, calcium, and folates. The plant may also have antioxidant effects.

5. Sanipanga

Sanipanga

Sanipanga is another natural dye of the Amazon, with leaves that can turn the skin a semi-permanent purple color. Among some indigenous groups, a spiritual belief is attached to the plant as well. If you can extract the purple color from the Sanipanga (Picramnia sp.) leaf by rubbing it into your fingers, you carry good spirits within you. If you fail to extract the color, on the other hand,  you might have bad spirits! Traditionally, the plant also has an antiseptic effect when rubbed into skin or wounds. This is another of the most important Medicinal plants in the Amazon rainforest.

6. Matico

Matico or buddleja globosa

Matico or Buddleja globosa. Photo by Wikimedia Commons

The colorful flowers of the Matico plant are eye-catching, but it is the leaves that hold their true magic. Amazon residents have long used Matico (Buddleja globosa) for muscle pain, sore throats, and other common ailments. Folks often boil the leaves in a tea to help with inflammation, body aches, or coughs. Now, scientists and companies outside the region have woken up to the plant’s usefulness too! Researchers have confirmed the ways Amazon peoples use Matico, finding that it has analgesic and anti-inflammatory properties, and can help to quickly heal scars or wounds.

7. Cordoncillo

Cordoncillo Medicinal plants in the amazon rainforest

In a traditional Medicinal Plant Garden, our guests may get the chance to chew on the Cordoncillo leaf, producing a slightly numbing effect many compare to Novocain. In fact, the Ese Eja People and other groups use it for exactly this reason! Cordoncillo has a variety of traditional uses, including disinfecting wounds, treating respiratory illnesses, stopping blood hemorrhages, and treating gallstones. Since the 1800s, the plant has become known globally as a hemostatic (to control/stop bleeding) and as an astringent for cuts.

  • What our guest say

    • Valuation Excellent
    • 5/5

Sue_szb April 2026

Beam May 2026

David Staro May 2026

Serg Averkin April 2026

Carlotta May 2026

Asha S May 2026

Laurence W April 2026

Isobel Griffith April 2026

Kay T April 2026

Nancy Hodgson March 2026

Lesly Lagos March 2026

Batya K. February 2026

Wow what an experience! If you want to be fully immersed in Amazon life in a wonderful , comfortable eco lodge, and not have expectations of a 5 star city hotel (I'm not sure why you would, but some reviewers seemed disappointed it wasn't!) you will love this. You will be in a group, 6 in ours, but you don't all have to do the same activities, you just join another group. Plenty of spaces to chill and downtime if you need it...its hot and humid! There's a fan in the room and I heard the superior rooms have a fan under the mozzie net. Take a torch! We were never bitten, used deet repellent only. They provide rubber boots if you want them, some of the trails were very muddy, but we managed in our walking boots. We loved the open wall to the jungle, despite some bugs, but not too many surprisingly. Sooooo much wildlife, all sorts of monkeys, otters, turtles, caiman, different birds, capybara etc. Luis M was our guide, a local, and he could spot a spider from 5 metres I'm sure... great sense of humour and a wealth of knowledge, loved him. We spent 3 nights 20th-24th April, it rained on a couple of occasions but not much. Perfect holiday for an immersive wildlife experience! Read all

Beautiful lodge in the rainforest, very well maintained and clean. We had a lot of fun and excellent guides. The rooms and facilities were top-notch! Read all

We stayed at Posada Amazonas Lodge in May 2026, and it was a truly unique experience. It’s important to note that the concept is unlike a traditional hotel: the rooms (the lodge has around 30 in total) are built entirely of wood and open completely to the rainforest, with no windows. The walls are about two meters high, and everything is open-air, meaning you can hear your neighbors as well as the sounds of the forest throughout the night. There is a hot-water shower with drainage flowing through wooden beams beneath the floor, and the beds are protected with mosquito nets. The food is delicious and nutritious, and one pleasant surprise was the excellent Wi-Fi connection (Starlink) available both at the lodge and on the boats. The logistics are flawless from the moment you land in Puerto Maldonado, including a short car ride (accompanied by a security company) followed by a forty-minute cruise along the Tambopata River. The staff is incredibly friendly. Our guide, Luis M. (a member of the local community that manages the lodge), was simply outstanding, with eagle-eyed vision for spotting wildlife and always wearing a smile. Tour highlights: Canopy Tower: a 42-meter tower rising above the treetops with panoramic views. We loved seeing the river, the rainforest, and even the distant Andes Mountains on the horizon. We returned at night during a nocturnal wildlife tour, where we spotted tarantulas, white sloths, and tree frogs. Lake Tres Chimbadas: a peaceful catamaran ride (without a motor) where Luis showed us a group of red-bellied monkeys, giant otters, and caimans. The scenery and tranquility are incredible. Trek to the “Great Tree”: a forest hike where we saw deer, jaguar tracks, a three-toed sloth, and more wildlife. At the end of the trail, we reached the gigantic ceiba tree: around 500 years old, approximately 60 meters tall, and with an impressive 11-meter base diameter. Highly recommended for anyone wanting to experience the true Amazon! Read all

An exceptional experience that truly exceeded all expectations. What impressed me the most is that here they genuinely want to make your stay as comfortable as possible — and that, to me, is what real high-level service is all about. The guide really tries to fill every excursion with emotions and memorable moments, turning simple activities into meaningful experiences. The kitchen team puts great effort into variety and introduces you to Peruvian cuisine — it feels like a small гастрономic journey. Housekeeping works like invisible bees — you don’t notice them, but everything is always perfectly taken care of. Another big highlight is the comfort level: stable electricity and surprisingly good internet both on the way and at the lodge, powered by Starlink. Having this level of connectivity in the middle of the jungle is something truly special. From reception and the bar to the boat driver — everyone is genuinely warm and happy to have you. You can really feel that each person is a small but important part of one big system delivering outstanding eco-tourism service. Bravo — achieving this level of service in the wild is not easy, and it shows. This experience was very valuable for me and my family. I won’t get tired of thanking you for the emotions you gave us. Highly recommended. Dear travelers — don’t hesitate. Go, enjoy the incredible nature and the level of service. This is something you will remember for a lifetime. Read all

We had the most amazing time at Refugio Amazonas for 3 nights, with a huge thanks to our guide Juan Carlos! On the first afternoon we sat down and planned our activities, which we loved! We came face to face with hundreds of birds, tarantulas, leaf carrying ants spanning 10 meter motorways to work and deliver the leaves to the ant house for food, parasites, and even leaves that cause natural dyes on oxidation - we learned so much. Carlos was genuinly interested in showing us everything the jungle had to offer, humorous and caring too. Carlos knew anything and everything about what was around us, pointing out things and creatures that the untrained eye would miss, carrying a telescope at all times for us to see the birds, ensuring we got magical videos on our phones using the telescope! Read all

Many thanks to Refugio Amazonas for an unforgettable experience! Brenda and team were so wonderful and accommodating, and Alan was a great guide. Thank you for a memorable experience! :) Read all

We had an excellent time at Tambopata research center. We are tourists like most who now visit the center, but it’s great to know that you can support research and the local community by visiting a place like this. Our guide for our trip, Esau, was extremely knowledgeable and showed great passion for his job. He described it as a hobby and he would get very excited if you spotted a specific bird or a tree. His specific knowledge about each and every creature in the forest was very impressive and I would recommend asking for Esau to be your guide in the future if you plan to visit. The hotel itself is unique. You are in the middle of the Amazon rainforest - the accessibility to nature is second to none. There are no windows in the hotel rooms. We had bugs in our room, of course, but the mosquito nets keep everything out and, actually, we both slept very well. The bar staff, Harrison, is very knowledgeable with drinks and works very hard. The food isn’t the best you’re ever going to have, but you have to remind yourself you are in the middle of the rainforest and that it takes a 6 hour round trip to get to the nearest town, and so the job that the hotel does in respect of the food is actually intuitive and very good. I would recommend this hotel to my peers and I would love to visit again in a few years time. Read all

We just finished a 4-night stay at Tambopata Research Center and it was the highlight of our entire Peru trip. From the first email with Mariella to being picked up at the airport to the actual stay itself, every step was smooth and every employee was attentive. Having never stayed in a lodge like this (this remote or exclusive), we were a little nervous about what to expect. Our guide, Timo was INCREDIBLE at tailoring all the activities to us. When he found out we liked more adventurous hikes, he took us on walks through swamps, bamboo forests, and little-used trails while always keeping an eye out for monkeys, birds, and insects. His knowledge of the wildlife, plants, and history of the area was beyond what we hoped for and he truly made the experience worth it. Read all

Spent 4 nights in mid April. I had high expectations and was not disappointed. Our guide Carmen picked us up at the airport and we saw monkeys already on our way to the lodge. We had a wonderful stay with exceptional food and activities everyday. Our guide Carmen was great and our itinerary was based on her suggestions however we could decide on what we would like to see. Wildlife is abundant, however, sometimes difficult to spot and photograph due to the low light. It rained a lot despite April being considered a transitioning time to dry season. But come on ... it's the rainforest. The clear highlight are the macaws which you can hear all time and also see from the tower and at the leks. Read all

This trip was the highlight of our travels through peru. The lodge was absolutely 5 stars for everything. The room, food, people. We had a private guide, Allen, who grew up locally and really had deep knowledge of the land, the history, and the variety of plant and animal species in the jungle. His knowledge and passion were invaluable to our experience. There are a variety of tour companies and lodges you can book to visit the Amazon, however, I would only recommend Rainforest Expeditions as they are truly connected to the community and offer high quality first class amazon experience! Read all

We had a truly wonderful stay with Rainforest Expeditions. Everyone was incredibly kind and welcoming, and our guide was fantastic — very knowledgeable and passionate about the rainforest. We saw many animals, even from the boat, which made the experience unforgettable. Read all

I just spent 3 days here with my family. The research center surpassed all our expectations. I want to give a special shout out to Carlos who took such good care of us. He went above and beyond to make sure we werr comfortable. And he was always smiling. He made us feel so welcome. We had Erik as our guide who is so knowledgeable and experienced. We learned so much, saw so much wildlife. It really was a dream vacation. Thank you!! Read all

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